AstraZeneca Pharmaceuticals LP Post Doc Fellow - Engineering of a ‘biological PROTAC’ in Cambridge, United Kingdom

Postdoctoral Long Title:

Characterisation and engineering of a specific intrabody to produce a biological PROTAC

We’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Cambridge, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technology experts in the industry, all collaborating on high-profile drug discovery projects. AstraZeneca have been at the centre of some of the biggest breakthroughs in oncology. In lung cancer, for example, we‘ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques, transcriptomics and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. Are you ready to use your knowledge of protein science and cell biology to impact on our understanding of a key oncology target?

AstraZeneca, Cambridge, UK, are looking for a Postdoctoral Scientist to join a novel project focused on using intracellular affinity tools as ‘biological PROTACs’ to enhance degradation of a specific target and bring about anti-tumour effects in target-dependent cells. You will join AstraZeneca at their new research centre and headquarters in Cambridge/UK. From within the AZ Affinity Reagents team, part of the Discovery Biology Department of Discovery Sciences, you will characterise key tools to progress your project and then move on to studying their effects in specific cancer models. You will be supported by a range of expertise, within and external to AZ, with the project aligned to an academic with deep knowledge of the activities of E3 Ligases and the functional effects of ubiquitination. You’ll have huge scope to explore new ideas and opportunities in energizing environments, with access to state of the art technology platforms, cutting-edge knowledge and experimental techniques.

Essential Education and Experience Required:

  • PhD in biology, biochemistry or a related discipline

  • Strong background and track record in protein science

  • Proven ability to work independently and collaborate in order to achieve objectives, as demonstrated by publications

  • Documented proficiency in the English language, both writing and speaking

  • Personal skills will be highly valued


  • Experience in affinity tool selection and engineering

  • Experience in the biomolecular characterisation of affinity tools, particularly against disordered proteins and/or intracellular targets

  • Understanding of E3 ligases and the functional effects of ubiquitination

  • Experience with oncology models

  • Cellular imaging techniques

  • PhD from a top-tier University

Skills and Capabilities required:

This role involves working as a lab-based postdoctoral investigator both in the areas of protein science and cell biology. As a strongly self-motivated and independent individual you will be adept at working across boundaries, enabling you to maximise value from the available resources. The role will involve implementing work-plans over timelines so that project objectives are met and carried out in accordance with Safety, Health & Environment standards, as well as our own and collaboration partner’s guidelines.

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Cambridge, UK with a competitive salary on offer

To apply for this position, please click the apply link below.

Advert opening date – 5th March 2018

Advert closing date – 13th May 2018

AstraZeneca welcomes applications from all sections of the community.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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